Table 2.

Local maxima of rCBF change over time^a

Region	Side	x	y	z	p	Voxels
Greater rCBF increases
Orbitofrontal cortex (11)	L	−4	32	−28	<0.001	413
Medial frontal gyrus (10)	L	−6	64	0	<0.001	789b
Anterior cingulate cortex (32)	R	8	54	8	<0.001	789b
Cerebellum	R	12	−78	−16	<0.001	138
Greater rCBF decreases
Insula	R	66	10	2	0.002	65c,d
Supramarginal gyrus (40)	R	64	−38	32	0.003	59d
Parieto-occipital cortex (18)	R	22	−62	36	<0.001	291
Lingual gyrus (18)	L	−20	−54	−2	<0.001	105
Thalamus	R	6	−10	8	0.003	59
Brainstem	R	18	−22	−8	<0.001	154

^aRegions where CI show differences in longitudinal rCBF change compared with CN in the full sample of participants. Stereotaxic coordinates are listed; Brodmann areas are indicated in parentheses.

^bRegions contained within the same cluster.

^cRegion that did not survive correction for tissue volume change over time.

^dRegions that were no longer significant in the age-matched analysis.