Table 3.
Rates of rCBF change over timea
| Baseline rCBF |
Annual rate of change |
Effective change | |||
|---|---|---|---|---|---|
| CN | CI | CN | CI | ||
| Greater rCBF increases | |||||
| Orbitofrontal cortex (11) | 75.17 (7.0) | 74.33 (8.4) | −0.35 | 0.18 | Increase in CI |
| Medial frontal gyrus (10) | 75.97 (4.5) | 74.81 (5.2) | −0.36 | 0.19 | Increase in CI |
| Anterior cingulate cortex (32) | 89.83 (5.3) | 89.08 (5.7) | −0.30 | 0.17 | Increase in CI |
| Cerebellum | 96.81 (7.1) | 97.36 (7.9) | −0.43 | 0.14 | Increase in CI |
| Greater rCBF decreases | |||||
| Insula | 41.60 (8.5) | 39.93 (8.5) | −0.22 | −0.82 | Greater decrease in CI |
| Supramarginal gyrus (40) | 81.32 (4.5) | 81.38 (5.3) | 0.00 | −0.38 | Greater decrease in CI |
| Parieto-occipital cortex (18) | 72.72 (6.1) | 71.99 (6.0) | 0.04 | −0.24 | Greater decrease in CI |
| Lingual gyrus (18) | 72.21 (8.3) | 71.54 (14.0) | −0.25 | −0.59 | Greater decrease in CI |
| Thalamus | 78.62 (8.6) | 76.78 (11.8) | −0.70 | −1.03 | Greater decrease in CI |
| Brainstem | 84.15 (5.4) | 84.59 (6.9) | 0.42 | 0.09 | Less increase in CI |
aAnnual rates of rCBF change and the effective direction of change for regions showing significant differences in longitudinal change between the CN and CI groups in Table 2. Baseline rCBF was not significantly different between the groups.