Figure 3.

Inhibition of PLCβ reduces the locomotor response of mice to direct and indirect dopamine agonists. Mice were pretreated with vehicle (VEH) or U73122 (10 mg/kg) and placed in locomotor activity chambers. A–D, After 30 min, mice were injected with 1 mg/kg apomorphine (APO; A), 2.5 mg/kg SKF81297 (B), 3 mg/kg amphetamine (AMPH; C), or 20 mg/kg cocaine (COC; D), and locomotor activity was monitored for another 60 min. Distance traveled (in centimeters) was measured over 5 min intervals, and total distance is shown as a sum of 60 min. Data are presented as the mean ± SEM. N = 8. **p < 0.01, Student's t test.