Table 3.
Predictors of HIV seropositivity in study population and their sensitivity and specificity
| Clinical variable | Sensitivity% (95% CI) | Specificity% (95% CI) | PPV% (95% CI) | NPV% (95% CI) |
|---|---|---|---|---|
| Prolonged diarrhoea |
23.9 (14.3 - 35.9) |
94.4 ( 90.0-97.3) |
61.5 (40.6 - 79.8) |
76.8 (70.7 - 82.2) |
| Chronic cough |
40.3 (28.5 - 53.0) |
95.5 (91.4 - 98.1) |
77.1 (59.9 - 89.6) |
81.0 (75.1 - 86.1) |
| Prolonged fever |
46.3 (34.0 - 58.9) |
92.2 (87.2 - 95.7) |
68.9 (53.4 - 81.8) |
82.1 (76.1 - 87.1) |
| Oral thrush |
68.7 (56.2-79.4) |
82.1 (75.7-87.4) |
59.0 (47.3-70.0) |
87.5 (81.5-92.1) |
| Generalised lymphadenopathy |
44.8 (32.6-57.4) |
98.3 (95.2-99.7) |
90.9 (75.7-98.1) |
82.6 (76.9-87.5) |
| Sensitivities and specificities of a clinical algorithm consisting of above variables | ||||
| No of parameters identified |
Sensitivity% |
Specificity% |
Correctly Classified% |
|
| ≥ 1 |
92.5 |
72.1 |
77.6 |
|
| ≥ 2 |
68.7 |
92.2 |
85.8 |
|
| ≥ 3 |
41.7 |
98.3 |
82.9 |
|
| ≥ 4 |
16.4 |
100.0 |
77.2 |
|
| 5 | 4.8 | 100.0 | 74.0 | |
PPV - Positive predictive value.
NPV - Negative predictive value.