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. 2013 Nov 1;27(21):2345–2355. doi: 10.1101/gad.223800.113

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Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — JNK suppresses energy expenditure. (A–D) Metabolic cage analysis of HFD-fed (4 wk) P^WT and P^ΔJ1,J2 mice was performed to measure energy expenditure (A), physical activity (B), oxygen consumption (V_O2) (C), and carbon dioxide release (V_CO2) (D). The data presented are the mean ± SEM (n = 6), and the statistical significance of differences is indicated. (E–G) ND-fed and HFD-fed (4 wk) P^WT and P^ΔJ1,J2 mice were examined in metabolic cages to measure food intake (E), water intake (F), and the respiratory exchange ratio (V_CO2/V_O2) (G). The data presented are the mean ± SEM (n = 6). No statistically significant differences between P^WT and P^ΔJ1,J2 mice were detected.