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. 2013 Nov 1;27(21):2356–2366. doi: 10.1101/gad.227512.113

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© 2013 Chuprin et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — MV induces cell fusion and senescence in normal human fibroblasts. (A) The MV-infected IMR-90 cells were stained with anti-SSPE antibody that recognizes MV proteins (red) and counterstained with DAPI. BrdU incorporation (B,C) and SA-β-gal activity (D) were assessed in IMR-90 cells infected with MV in syncytium (Syn) and mononuclear cells (Mono). (E) Protein content of p53 and p21 was assessed by immunoblotting in MV-infected or mock-infected (Ctrl) IMR-90 cells. Expression of MCM2, MCM3, CDCA2, and CDCA8 (F); IL-6, IL-8, CXCL-1, and CCL5 (G); and MICA and ULBP2 (H) in MV-infected or mock-infected (Ctrl) IMR-90 cells assayed by quantitative RT–PCR. Values are means + SEM; (*) P < 0.05.