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. 2013 Nov 1;27(21):2367–2379. doi: 10.1101/gad.226621.113

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© 2013 Alfieri et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 6. — The PhoRC complex is a hub for multiple interactions. The Pho:Sfmbt interaction is required for the PcG-repressive function on HOX genes. The Pho/YY1 protein (orange) is recognizing the Pho-binding sites (gray and white) in a PRE through its DNA-binding domain (PDB ID: 1ubd) (Houbaviy et al. 1996) and recruits the Sfmbt 4MBT domain through its spacer region (miniPhoRC crystal structure) (this study). Pho regions flanking the spacer and connecting it to the DNA-binding domain are predicted to be disordered (dotted line). The Sfmbt MBT repeats are colored as above. Sfmbt also interacts with Scm and thereby tethers PRC1. Interaction of the fourth MBT repeat of Sfmbt with mono- or dimethylated lysines in histone tails (red) (PDB ID: 3h6z) (Grimm et al. 2009) links the PhoRC complex with nucleosomes.