Table 1. Number of Cocaine Injections, Food Pellets, and Total Reinforcers Earned Per Component of the Cocaine vs Food Choice Session under the Different Experimental Conditions.
| C1 | C2 | C3 | C4 | C5 | |
|---|---|---|---|---|---|
| Choice session only | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 0.8 (0.8) | 10 (0) | 8.8 (0.2) |
| Food pellets | 10 (0) | 9.8 (0.2) | 9.0 (0.9) | 0 (0) | 0 (0) |
| Total SR | 10 (0) | 9.8 (0.2) | 9.8 (0.2) | 10 (0) | 8.8 (0.2) |
| + Extended access—7 days | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 1.5 (1.0) | 5.6 (1.7) | 7.1 (1.6) |
| Food pellets | 9.6 (0.4) | 9.2 (0.5) | 7.5 (1.1) | 3.1 (1.4) | 0 (0) |
| Total SR | 9.6 (0.4) | 9.2 (0.5) | 9.0 (0.8) | 8.7 (1.3) | 7.1 (1.6) |
| + Extended access—14 days | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 0.8 (0.8) | 6.4 (2.1) | 8.3 (1.1) |
| Food pellets | 9.8 (0.3) | 8.2 (1.1) | 6.4 (1.5) | 2.7 (1.6) | 0.2 (0.2) |
| Total SR | 9.8 (0.3) | 8.2 (1.1) | 7.3 (1.0) | 9.1 (0.8) | 8.4 (0.9) |
| +0.32 mg/kg/h PDM—7 days | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 0 (0) | 5.9 (1.4) | 6.1 (1.0) |
| Food pellets | 7.3 (1.6) | 7.6 (.4) | 7.7 (1.4) | 2.6 (1.0) | 0.3 (0.3) |
| Total SR | 7.3 (1.6) | 7.6 (1.4) | 7.7 (1.4) | 8.4 (1.6) | 6.4 (0.8) |
| + 1.0 mg/kg/hPDM—7 days | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 0.4 (0.4) | 2.5 (2.5) | 3.9 (1.7) |
| Food pellets | 8.3 (1.7) | 7.9 (1.4) | 7.2 (174) | 5.0 (2.0) | 0.8 (0.8) |
| Total SR | 8.3 (1.7) | 7.9 (1.4) | 7.6 (1.6) | 7.5 (.4) | 4.7 (1.3) |
| +1.0 mg/kg/h PDM—14 days | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0 (0) | 0 (0) | 0 (0) | 1.7 (1.1) | 3.8 (1.8) |
| Food pellets | 7.9 (0.9) | 5 (2) | 7 (1.4) | 4.1 (1.7) | 3.9 (2.2) |
| Total SR | 7.9 (0.9) | 5 (2) | 7 (1.4) | 5.8 (1.7) | 7.6 (1.4) |
| Choice session only | 0 | 0.0032 | 0.01 | 0.032 | 0.1 |
| Cocaine injections | 0.1 (0.1) | 0 (0) | 1.3 (1.3) | 10 (0) | 9.8 (0.1) |
| Food pellets | 9.9 (0.1) | 9.7 (0.3) | 8.7 (1.3) | 0 (0) | 0.1 (0.1) |
| Total SR | 10 (0) | 9.7 (0.3) | 10 (0) | 10 (0) | 9.9 (0.1) |
| No cocaine—7 days | 0 | 0 | 0 | 0 | 0 |
| Injections | 0 (0) | 0 (0) | 0 (0) | 0.1 (0.1) | 4 (1.8) |
| Food pellets | 10 (0) | 10 (0) | 10 (0) | 9.9 (0.1) | 6 (1.8) |
| Total SR | 10 (0) | 10 (0) | 10 (0) | 10 (0) | 10 (0) |
| No cocaine—14 days | 0 | 0 | 0 | 0 | 0 |
| Injections | 0 (0) | 0 (0) | 0 (0) | 1.2 (1.1) | 4.3 (2.2) |
| Food pellets | 10 (0) | 10 (0) | 10 (0) | 8.8 (1.1) | 5.7 (2.2) |
| Total SR | 10 (0) | 10 (0) | 10 (0) | 10 (0) | 10 (0) |
The corresponding unit-cocaine dose available in each component of the choice procedure is shown in mg/kg/injection. All data represent the group mean (±SEM) of the last 3-day means for each monkey for each experimental condition. The bold entries represent the unit cocaine dose that was available during each component of the choice session.