Table 1. Significant Clusters from the fMRI Analyses.

	Hemisphere	Cluster size	Cluster P-value	Peak T-value	Coordinate
					X	Y	Z
Perceptual load task:
High>low load (see also Figure 2b)
Parietal/occipital cortex	Left	1572	<0.001	9.41	−28	−56	52
	Right	543	<0.001	7.42	30	−54	50
Anterior insula	Left	246	<0.001	6.90	−30	24	0
	Right	326	<0.001	8.34	34	22	−4
Precentral PFC	Left	575	<0.001	7.28	−44	4	36
	Right	128	<0.001	6.15	40	6	32
Midfrontal PFC	Left	50	<0.001	6.63	−28	0	50
	Right	22	<0.01	5.48	28	0	50
Temporal/fusiform cortex	Left	136	<0.001	6.31	−48	−60	−10
Dorsal ACC/SMC	Left/right	620	<0.001	7.71	−2	16	50
Placebo>Zembrin (low load: fear>neutral) (see also Figure 3b)
Amygdala	Left	58	<0.01a	3.81	−26	0	−18
Amygdala	Right	13	<0.05a	3.56	24	4	−20
Dorsal striatum	Left	390	<0.05b	4.51	−10	0	16
Dorsal Striatum	Right	629	<0.01b	5.36	26	4	18
Precuneus	Left/right	230	<0.05b	4.03	−12	−30	42
Emotion matching task:
Emotion>shape matching (see also Figure 4a)
Fusiform cortex/cerebellum	Left	337	<0.001	8.56	−38	−46	−20
	Left	82	<0.001	6.77	−36	−70	−20
	Right	2546	<0.001	11.72	40	−42	−22
Frontal-inferior PFC	Left	263	<0.001	6.50	−42	12	26
	Right	718	<0.001	8.33	42	16	24
Temporal cortex	Left	190	<0.001	6.02	−26	16	−30
	Right	88	<0.001	6.86	48	−54	8
	Right	104	<0.001	6.36	56	−38	10
Amygdala	Left	107	<0.001	6.28	−24	0	−20
	Right	110	<0.001	6.59	22	−4	−16
Hippocampus	Left	90	<0.001	6.44	−22	−24	−4
	Right	36	<0.01	6.09	22	−26	−4
Brainstem	Right	21	<0.01	5.70	18	−32	−48
Precentral PFC	Right	43	<0.01	5.63	48	0	52
Ventro-medial PFC/OFC	Left	220	<0.001	5.17	−24	16	−26
		85	<0.01	4.52	−32	28	−4
Ventro-medial PFC/OFC	Right	458	<0.001	5.22	20	12	−24
Midbrain	Left/Right	427	<0.001a	6.03	−20	−28	−4
Hypothalamus	Left/right	53	<0.05a	4.65	2	2	−18
Functional connectivity with amygdala: placebo>Zembrin
Main effect (see also Figure 4b)
Hypothalamus	Left/right	8	<0.05a	3.64	0	−8	−8
Emotion>shape matching
Hypothalamus	Left/right	13	<0.10a	2.76	0	−2	−4
Emotion matching
Hypothalamus	Left/right	47	<0.05a	3.73	−2	0	−6

Abbreviations: ACC, anterior cingulate cortex; OFC, orbitofrontal cortex; PFC, prefrontal cortex; SMC, supplementary motor cortex.

All effects are whole-brain FWE-corrected with an extend threshold of 20 voxels unless stated otherwise. Coordinates refer to MNI space.

^aFWE-corrected for ROI volume.

^bFWE-corrected cluster-threshold with uncorrected cluster-defining threshold P<0.001.