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. 2013 Nov 15;3:281. doi: 10.3389/fonc.2013.00281

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Copyright © 2013 Thiel and Ristimäki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAS-RAF pathway and immunohistochemical staining of colorectal cancer specimens with BRAF V600E mutation specific monoclonal antibody. (A) Strong immunopositivity in cancer cells with a BRAF V600E mutation. (B) No staining of cancer cells in a specimen without BRAF V600E mutation. Original magnifications are 200×. (C) Schematic RAS-RAF pathway (orange boxes) and inhibitors of components of this pathway (blue boxes). Arrows indicate an activation process, and blocked arrows an inhibition process.