Table 1. Data sources. All data sources used in this disease association study, their size, and edge density. Relation matrices Rij relate objects of two different types and their numbers are reported separately (delimited by a forward slash).
Matrix | Data description | # Nodes | # Edges | Density | Reference |
---|---|---|---|---|---|
Θ1(1) | Protein-protein interactions | 10,360 | 55,787 | 0.00104 | BioGRID v3.1.9451 |
Θ1(2) | Gene co-expression | 539 | 869 | 0.006 | Prieto et al.52 |
Θ1(3) | Cell signalling data | 1,217 | 7,517 | 0.01016 | KEGG53 |
Θ1(4) | Genetic interactions | 542 | 511 | 0.00349 | BioGRID v3.1.9451 |
Θ1(5) | Metabolic network | 5,908 | 1,505,831 | 0.0863 | KEGG53 |
Θ4 | Drug interaction data | 4,477 | 21,821 | 0.00218 | DrugBank v3.054 |
Θ3 | GO semantic structure | 11,853 | 43,924 | 0.00063 | Gene Ontology28 |
Θ2 | DO semantic structure | 1,536 | 1,098 | 0.00093 | Disease Ontology1 |
R13 | Gene annotations | 17,428/11,853 | 100,685 | 0.00049 | Gene Ontology28 |
R14 | Drug-target relationships | 1,978/4,477 | 7,977 | 0.00009 | DrugBank v3.054 |
R12 | Gene-disease relationships | 5,267/1,536 | 22,084 | 0.00273 | Mapped GeneRIF55 |