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. 2013 Dec;94(6):1309–1315. doi: 10.1189/jlb.0113043

Figure 1. Effect of AR agonists and IL-10 on TIMP-1 production by macrophages.

Figure 1.

TIMP-1 production by RAW 264.7 cells treated with 100 μM adenosine (ado; A), 0.1 μM NECA, CGS21680, or BAY606583 (B), and/or 10 ng/ml IL-10 for 24 h. *P < 0.05, **P < 0.01 versus vehicle #P < 0.05; ###P < 0.001 versus IL-10. ve, Vehicle. (C) TIMP-1 production by BMDMs isolated from WT, A2AAR, or A2BAR KO mice and treated with 1 μM NECA and/or 10 ng/ml IL-10 for 6 h. *P < 0.05, ***P < 0.001. (D) TIMP-1 production by RAW 264.7 cells treated with increasing concentrations of PSB0788, 30 min before treatment with 1 μM NECA and 10 ng/ml IL-10 for 24 h. ###P < 0.001 versus vehicle (NECA+IL-10). All results (mean±sem) are representative of at least three independent experiments (n=5 in each experiment).