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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Nat Rev Immunol. 2010 Sep 17;10(10):10.1038/nri2848. doi: 10.1038/nri2848

Figure 1. The IL-9 receptor signalling complex.

Figure 1

Interleukin-9 (IL-9) activates a heterodimeric receptor that consists of the IL-9 receptor α-chain (IL-9Rα) and the γ-chain and promotes the crossphosphorylation of Janus kinase 1 (JAK1) and JAK3. This leads to the activation of signal transducer and activator of transcription 1 (STAT1), STAT3 and STAT5 and the upregulation of IL-9-inducible gene transcription.