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. 2013 Nov 15;7:180. doi: 10.3389/fncir.2013.00180

FIGURE 8.

FIGURE 8

Conditioned eyeblink responses (CRs) are extinguished in cbln1-/- mice. (A) A diagram showing a sequence of experiments: cbln1-/- mice were injected with Cbln1 as described in Figure 3 and trained for delay EBC (T1–T7) beginning 2 days after the Cbln1 injection. From day 40 (30 days after T7), mice were given extinction sessions (E1–E4), in which only a CS tone was given, 100 times per day, to examine the extinction of learned responses. (B) Intact extinction of conditioned eyeblink responses in cbln1-/- mice. The CR% dramatically decreased in both wild-type mice (n = 7) and cbln1-/- mice injected with Cbln1 (n = 7; ***p < 0.01, T7 vs. E4 in each group, by Mann–Whitney’s U test). During extinction sessions (E1–E4), no difference in CR% was observed between wild-type mice and cbln1-/- mice injected with Cbln1 (p > 0.1, a two-way repeated measures ANOVA, n = 7 for each group). (C) The CR% was similar between wild-type mice and cbln1-/- mice injected with Cbln1 at E4 as well as at T7 (p > 0.1, by Mann–Whitney’s U test, n = 8 for each group).