Table 1.
Characteristics* of 806 Framingham Offspring participants in a study of plasma Procollagen Type III N-terminal peptide (P3NP) and muscle function, overall and by sex-specific plasma P3NP quartiles
| Mean plasma P3NP (mg/L), (range) | Age (yrs) | BMI (kg/m2) | Current smoker (%) | Alcohol (drinks/week) | Oral estrogen (%) | Total lean mass (kg)† | Appendicular lean mass (kg)† | Quadriceps strength (kg) | |
|---|---|---|---|---|---|---|---|---|---|
| Total sample (n=806) | |||||||||
| Total sample | 4.0 (0.02, 53.3) | 57.6± 9.6 | 27.0 ± 5.0 | 16.6 | 1.7 ± 2.4 | - | 42.9± 10.3 | 19.0 ± 5.1 | 19.9 ± 6.4 |
| Men (n=324) | |||||||||
| Total men | 3.9 (0.5–36.5) | 57.4±10.0 | 27.7 ± 4.0 | 11.1 | 2.5 ± 3.0 | - | 54.6 ± 6.5 | 24.2 ± 3.3 | 22.7 ± 6.7 |
| Men: Quartile 1 | 2.1 (0.5–2.6) | 52.8±8.8‡ | 26.7±3.1‡ | 18.5 | 3.1±3.0 | - | 55.6±6.2 | 24.0±3.0 | 22.9±7.0 |
| Men: Quartile 2 | 3.0 (2.6–3.4) | 56.5±9.0‡ | 27.0±4.0* | 8.6 | 2.5± 2.9 | - | 53.0±6.7 | 22.9±3.4 | 22.2±6.3 |
| Men: Quartile 3 | 3.8 (3.4–4.2) | 59.1±9.1‡ | 28.3±3.9‡ | 8.6 | 2.3± 3.2 | - | 55.4±6.7 | 23.8±3.3 | 22.9±6.5 |
| Men: Quartile 4 | 6.8 (4.2–36.5) | 61.1±10. 5‡ | 28.7±4.4‡ | 8.6 | 2.2± 2.9 | - | 54.6±6.4 | 23.4±3.1 | 22.7±7.1 |
| Pre-menopausal women (n=114) | |||||||||
| Total pre-menopausal women | 4.1 (0.6–19.9) | 47.2± 4.7 | 26.0± 5.7 | 15.8 | 1.1 ± 1.5 | - | 37.6 ± 4.6 | 16.4 ± 2.7 | 19.8 ± 5.4 |
| Pre-menopausal women: Quartile 1 | 1.7 (0.6–2.2) | 46.9±4.1 | 23.8± 3.1§ | 25.0 | 1.3 ± 1.4§ | - | 38.1±3.7 | 16.4±2.2 | 18.1±5.3 |
| Pre-menopausal women: Quartile 2 | 2.7 (2.3–3.1) | 47.0 ±5.7 | 25.0 ± 4.2§ | 17.2 | 1.7 ± 1.6§ | - | 37.6±4.6 | 16.0±2.3 | 21.4±5.2 |
| Pre-menopausal women: Quartile 3 | 3.6 (3.1–4.2) | 47.3 ± 4.4 | 27.6±7.6§ | 6.9 | 0.5 ± 0.9§ | - | 37.9±5.0 | 16.3±2.9 | 19.5±4.9 |
| Pre-menopausal women: Quartile 4 | 8.4 (4.3–19.9) | 47.5 ± 4.9 | 27.7±6.0 § | 14.3 | 1.0 ± 1.6§ | - | 36.9±5.0 | 15.9±2.9 | 20.2±6.0 |
| Post-menopausal women (n=368) | |||||||||
| Total post-menopausal women | 4.0 (0.02–53.3) | 61.0 ± 8.1 | 26.8 ±5.5 | 16.9 | 1.2 ± 1.9 | 36.1 | 35.8 ± 4.2 | 15.4 ± 2.4 | 17.6 ± 5.4 |
| Post-menopausal women: Quartile 1 | 1.9 (0.02–2.4) | 58.1 ± 7.1‡ | 25.9 ± 5.2‡ | 16.3 | 1.2 ± 1.7 | 46.7§ | 36.0±4.0 | 15.2±2.1 | 17.9±5.8 |
| Post-menopausal women: Quartile 2 | 2.7 (2.5–3.0) | 61.6 ± 7.5‡ | 25.9 ± 4.4‡ | 19.6 | 1.2 ± 2.0 | 39.1§ | 35.3±3.8 | 14.8±1.9 | 17.8±4.8 |
| Post-menopausal women: Quartile 3 | 3.4 (3.0–3.9) | 61.4 ± 8.2‡ | 27.0 ± 5.8‡ | 14.1 | 1.0 ± 1.6 | 29.4§ | 35.8±4.2 | 15.0±2.2 | 17.3±5.1 |
| Post-menopausal women: Quartile 4 | 7.8 (3.9–53.3) | 62.8 ± 8.9‡ | 28.3 ± 6.1‡ | 17.4 | 1.4 ± 2.2 | 29.4§ | 36.0±4.8 | 15.2±2.3 | 17.3±5.9 |
*
mean ± standard deviation unless otherwise specified
†
among 687 subjects with both a measure of P3NP and total body lean mass
‡
P<0.01
§
P<0.05