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. 2013 Sep 9;2(11):1203–1213. doi: 10.1242/bio.20136262

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — (A) The consensus Gli binding site (GBS). (B) Profile of Gli2a ChIP-seq sequence enrichment at the ptch1 genomic locus. (C) Predicted GBS located within each peak (I–IV) and their conservation between different species. (D) Profile of Gli2a ChIP-seq sequence enrichment at the ptch2 genomic locus. (E) Predicted GBS located within each peak (I–III) and their conservation between different species. (F) Transient expression of GFP driven by a wild-type −8 kb ptch2 promoter fragment that includes the Peak I GBS. (G) Transient expression of the same reporter in which the GBS is mutated.