Table 2.
Effects of B6 (B) and C3H (C) Alleles in Different QTLs on Atherosclerosis and Plasma Lipids in the Intercross Between B6.Apoe−/− and C3H.Apoe−/− Mouse Strains
| Locus Namea | Chr | Trait | LOD | Peak, cM | Closest Marker | BB | BC | CC | P Value |
|---|---|---|---|---|---|---|---|---|---|
| Ath28 | 2 | Lesion (nonparametric) | 3.59 | 100.5 | D2Mit148 | 12 595±12 897 (n=73) | 10 848±10 165 (n=99) | 28 271±36 479 (n=56) | 1.8E−06 |
| Ath8 | 4 | Lesion (nonparametric) | 3.81 | 31.6 | D4Mit139 | 15 296±13 347 (n=59) | 16 945±22 166 (n=104) | 12 520±24 876 (n=73) | 0.396 |
| Athsq1 | 4 | Lesion (nonparametric) | 2.14 | 77.6 | D4Mit33 | 15 861±24 952 (n=53) | 17 479±23 433 (n=118) | 10 616±12 244 (n=59) | 0.136 |
| Ath31 | 7 | Lesion (nonparametric) | 2.25 | 59.1 | D7Mit330 | 17 873±27 165 (n=56) | 16 152±20 439 (n=118) | 11 153±16 419 (n=60) | 0.198 |
| Ath29 | 9 | Lesion (nonparametric) | 5.40 | 44.2 | D9Mit236 | 22 162±22 430 (n=54) | 15 020±20 472 (n=120) | 10 123±20 992 (n=63) | 9.26E−03 |
| Ath33 | 15 | Lesion (nonparametric) | 5.92 | 37.8 | D15Mit188 | 9386±11 194 (n=48) | 14 341±23 011 (n=120) | 24 495±25 337 (n=50) | 1.95E−03 |
| Ath30 | 1 | Lesion (parametric) | 2.34 | 39.2 | D1MIT161 | 16 369±17 243 (n=53) | 16 027±22 747 (n=121) | 13 748±22 869 (n=58) | 0.765 |
| Ath1 | 1 | Lesion (parametric) | 2.1 | 78 | D1Mit270 | 17 752±24 695 (n=64) | 16 318±23 341 (n=102 | 11 913±14 121 (n=67) | 0.261 |
| Ath28 | 2 | Lesion (parametric) | 3.24 | 100.5 | D2Mit148 | 12 595±12 897 (n=74) | 10 848±10 165 (n=99) | 28 271±36 479 (n=56) | 1.8E−06 |
| Ath8 | 4 | Lesion (parametric) | 3.30 | 33.6 | D4Mit178 | 14 252±12 034 (n=56) | 19 297±28 313 (n=107) | 10 376±12 777 (n=69) | 2.41E−02 |
| Athsq1 | 4 | Lesion (parametric) | 2.65 | 75.6 | D4Mit33 | 15 861±24 952 (n=53) | 17479±23433 (n=118) | 10 616±12 244 (n=59) | 0.136 |
| Ath31 | 7 | Lesion (parametric) | 2.77 | 61.1 | D7Mit330 | 17 873±27 165 (n=56) | 16152±20439 (n=118) | 11 153±16 419 (n=60) | 0.198 |
| Ath29 | 9 | Lesion (parametric) | 3.65 | 46.2 | D9Mit236 | 22 162±22 430 (n=54) | 15 020±20 472 (n=120 | 10 123±20 992 (n=63) | 9.26E−03 |
| Ath33 | 15 | Lesion (parametric) | 4.33 | 25.8 | D15Mit143 | 9107±10943 (n=47) | 14 181±21 364 (n=127) | 22 794±25 419 (n=62) | 2.41E−03 |
| Hdlq5 | 1 | HDL | 7.30 | 67.71 | D1Mit425 | 64.8±45.3 (n=63) | 107.1±61.3 (n=113) | 114.1±66.7 (n=55) | 2.9E−06 |
| Hdlq16 | 8 | HDL | 2.11 | 17.7 | D8Mit191 | 81.0±53.3 (n=56) | 107.9±66.8 (n=134) | 83.5±49.3 (n=43) | 6.5E−03 |
| Hdlq17 | 9 | HDL | 3.04 | 0 to 34 | D9Mit297 | 81.1±53.8 (n=65) | 95.0±62.8 (n=105) | 116.2±63.8 (n=64) | 4.80E−03 |
| Hdlq54 | 9 | HDL | 3.55 | 43.91 | D9Mit236 | 73.2±48.7 (n=55) | 95.8±60.6 (n=120) | 120.2±66.7 (n=61) | 1.8E−04 |
| Hdlq18 | 12 | HDL | 2.81 | 12.04 | D12Mit84 | 77.7±52.5 (n=60) | 112.3±65.5 (n=98) | 92.8±60.6 (n=73) | 2.1E−03 |
| Lipq2 | 13 | HDL | 3.05 | 64.72 | D13Mit151 | 73.1±49.1 (n=55) | 101.8±60.0 (n=116) | 108.4±70.2 (n=64) | 3.7E−03 |
| Cq1 | 1 | Non‐HDL | 4.92 | 75.67 | D1Mit270 | 696.2±341.6 (n=61) | 859.7±363.9 (n=101) | 976.9±332.6 (n=69) | 4.3E−05 |
| Chol8 | 4 | Non‐HDL | 2.51 | 13.55 | D4Mit192 | 938.6±353.6 (n=48) | 873.3±361.4 (n=106) | 730.4±344.9 (n=75) | 3.1E−03 |
| Nhdlq12 | 12 | Non‐HDL | 6.59 | 54.04 | D12mit277 | 865.6±291.4 (n=49) | 909.7±373.4 (n=148) | 575.3±265.7 (n=38) | 1.1E−06 |
| Chldq8 | 14 | Non‐HDL | 2.24 | 29.37 | D14MIT155 | 743.9±336.3 (n=68) | 869.0±359.5 (n=109) | 941.3±377.4 (n=54) | 8.1E−03 |
| Nhdlq9 | 15 | Non‐HDL | 2.43 | 51.82 | D15Mit161 | 830.6±327.7 (n=54) | 798.9±364.9 (n=123) | 977.1±358.8 (n=56) | 7.9E−03 |
| Nhdlq2 | X | Non‐HDL | 2.22 | 24.59 | DXMit81 | 804.2±366.2 (n=110) | 875.9±358.2 (n=116) | 1.4E−01 | |
| Tglq1 | 1 | Triglyceride | 6.42 | 77.67 | D1Mit270 | 111.6±26.2 (n=61) | 135.5±41.6 (n=102) | 148.5±48.0 (n=69) | 1.9E−06 |
| Tgq10 | 2 | Triglyceride | 2.62 | 49.35 | D2Mit126 | 117.4±34.5 (n=57) | 139.3±46.9 (n=124) | 135.7±35.6 (n=53) | 4.6E−03 |
| Tgq28 | 16 | Triglyceride | 2.51 | 9.66 | D16Mit165 | 133.5±48.7 (n=68) | 140.9±42.7 (n=97) | 119.0±31.5 (n=62) | 3.7E−03 |
Data are mean±SD. The units for these measurements are μm2/section for atherosclerotic lesions and mg/dL for plasma lipid levels. The number in the brackets represents the number of progeny with a specific genotype at a peak marker. ANOVA was used to determine the significance level (P value) of differences for a specific phenotype among progeny with different genotypes at a specific marker. The significant LOD scores were highlighted in bold. BB indicates homozygous for B6 alleles at the linked peak marker; CC, homozygous for C3H alleles; BC, heterozygous for B6 and C3H alleles at the peak marker; QTL, quantitative trait locus; Chr, chromosome; LOD, logarithm of odds.