Table 4.
QTLs for Atherosclerosis and Plasma Lipids Identified in the Present Male Versus the Previously Reported Female F2 Cohort Derived From B6.Apoe−/− and C3H.Apoe−/− Mice
| Locus Name | Chr | Trait | LOD (Male) | LOD (Female) |
|---|---|---|---|---|
| Ath30 | 1 | Lesion | 2.34 | … |
| Ath1 | 1 | Lesion | 2.10 | … |
| Ath28 | 2 | Lesion | 3.59 | … |
| Ath8 | 4 | Lesion | 3.30 | … |
| Athsq1 | 4 | Lesion | 2.65 | … |
| Ath31 | 7 | Lesion | 2.77 | … |
| Ath29 | 9 | Lesion | 3.65 | 4.1 |
| Ath19 | 11 | Lesion | … | 2.4 |
| Ath33 | 15 | Lesion | 4.33 | … |
| Hdlq5 | 1 | HDL | 7.30 | 3.0 |
| Hdlq21 | 3 | HDL | … | 2.3 |
| Hdlq16 | 8 | HDL | 2.11 | … |
| Hdlq17 | 9 | HDL | 3.04 | … |
| Hdlq54 | 9 | HDL | 3.55 | … |
| Hdlq18 | 12 | HDL | 2.81 | … |
| Lipq2 | 13 | HDL | 3.05 | … |
| Cq1 | 1 | Non‐HDL | 4.92 | 6.3 |
| Chol8 | 4 | Non‐HDL | 2.51 | … |
| Chldq3 | 5 | Non‐HDL | … | 2.2 |
| Nhdlq11 | 9 | Non‐HDL | … | 2.5 |
| Nhdlq12 | 12 | Non‐HDL | 6.59 | … |
| Chldq8 | 14 | Non‐HDL | 2.24 | … |
| Nhdlq9 | 15 | Non‐HDL | 2.43 | … |
| Nhdlq2 | X | Non‐HDL | 2.22 | … |
| Tglq1 | 1 | Triglyceride | 6.42 | 3.8 |
| Tgq10 | 2 | Triglyceride | 2.62 | … |
| Trigg2 | 8 | Triglyceride | … | 3.2 |
| Tgq28 | 16 | Triglyceride | 2.51 | … |
QTL indicates quantitative trait locus; Chr, chromosome; LOD, logarithm of odds; male: the present male F2 cohort derived from B6.Apoe−/− and C3H.Apoe−/− mice; female: the female F2 cohort derived from B6.Apoe−/− and C3H.Apoe−/− mice previously reported by our group.7 The significant LOD scores were highlighted in bold.