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. 2013 Aug 23;2(4):e000197. doi: 10.1161/JAHA.113.000197

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 6. — Effects of renal denervation on renal NCC (A), WNK4 (B), SGK‐1 (C), ENaC (D), and AT1 receptor (E) in SHRcp rats. Upper panels show representative Western blots. Each protein value in individual rats was normalized to β‐actin. The same membranes were consecutively reprobed with WNK4 (B), AT1 receptor (E), and β‐actin. Therefore, representative Western blot bands of β‐actin were the same in (B) and (E), and representative β‐actin bands are not shown in (E). Values are mean±SEM (n=5 to 6 in each group). NCC/β‐actin was significantly influenced by strain (P<0.05). However, WNK4, SGK‐1, αENaC, and AT1 receptor were not influenced by strain. NCC indicates Na⁺‐Cl⁻ cotransporter; WNK‐4, with‐no‐lysine‐kinase 4; SGK, serum and glucocorticoid‐induced protein kinase; ENaC, epithelial sodium channel; AT1, angiotensin type I; SHRcp, SHR/NDmcr‐cp(+/+); SEM, standard error of the mean; WKY, sham‐operated Wistar‐Kyoto rats; Cont, sham‐operated SHRcp rats; RD, SHRcp rats subjected to renal denervation; NS, not significant.