Figure 2.

Myocardial oxygen consumption rate (MVO₂) in RELOAD. The time‐course of changes in MVO₂ (A), oxygen content in the coronary vessels (B), and coronary flow (C). MVO₂ was markedly decreased with ventricular unloading (*P<0.05 vs baseline), and increased more than baseline by RELOAD (*P<0.05 vs baseline). Substrate infusion itself did not lead to change MVO₂. Moreover difference between arterial and venous oxygen content was significantly decreased during ECMO, whereas coronary flow was significantly increased by RELOAD (*P<0.05 vs baseline). Values are means±SE; n=8. ECMO indicates extracorporeal membrane oxygenation; SE, standard error; A‐V, difference between arterial and venous oxygen content.