Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Aug 23;2(4):e000106. doi: 10.1161/JAHA.113.000106

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Figure 4. — Pyruvate decarboxylation (PDC). A, Fractional substrate contribution (FC) to acetyl‐CoA by ¹³C‐NMR from left ventricular tissues at the end of the protocol. FC‐pyruvate significantly decreased and FC of unlabeled substrates increased, while FC‐leucine maintained with RELOAD when compared to UNLOAD animals. B, PDC‐to‐citrate synthase (CS) flux ratio by GC‐MS. RELOAD significantly decreased PDC/CS. C, Absolute PDC flux calculated by MVO₂ and PDC/CS. Values are means±SE; n=6 to 8 per group. *P<0.05, ^†P<0.01 compared with UNLOAD. NMR inidcates nuclear magnetic resonance; GC‐MS, gas chromatography/mass spectroscopy; MVO₂, myocardial oxygen consumption rate; SE, standard error; CAC, citric acid cycle.