Table 1.
Major pro-angiogenic and anti-angiogenic mediators
| Type of mediator | Molecule |
|---|---|
| Pro-angiogenic | VEGF |
| FGF-2 | |
| PlGF | |
| SDF-/XCL12 | |
| PDGF | |
| TGF-α and -β | |
| ET-1 | |
| Hepatocyte growth factor (HGF) | |
| Platelet activating factor (PAF) | |
| TNF-α | |
| Insulin-like growth factor (IGF) | |
| Angiopoietin-1 | |
| Granulocyte colony-stimulating factor (G-CSF) | |
| Granulocyte-macrophage colony-stimulating factor (GM-CSF) | |
| Erythropoietin | |
| MCP-1 | |
| Tissue kallikrein | |
| Fractalkine/CX3CL1 | |
| IL-6 | |
| IL-8 | |
| Anti-angiogenic | Angiostatin |
| Endostatin | |
| Thrombospondin-1 | |
| IFN-α and -γ | |
| PTX3 | |
| IL-12 | |
| Angiopoietin-2 | |
| Tissue inhibitors of metalloproteinases | |