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The HDAC family. HDACs can be classified according to their homology in the catalytic domain into class I (HDAC1, 2, 3 and 8), class II (HDAC4, 5, 6, 7, 9 and 10) and class IV (HDAC11) enzymes. Class II is subdivided depending onto the presence of one (class IIa) or two (class IIb) catalytic domains. The NAD±-dependent sirtuin protein deacetylases, SIRT1–7, represent class III. aa: amino acids.
