HDAC1 |
• Co-expression of HIF-1α and HDAC1 correlates with poor prognosis |
[19] |
|
• Included in a SNAIL recruited repressor complex that controls E-cadherin expression, EMT and metastasis |
[54] |
HDAC2 |
• Overexpressed, especially in G2 (moderately-) and G3 (un-) differentiated PDAC |
[20] |
|
• Mediates resistance towards DNA-damage induced apoptosis by controlling expression of the pro-apoptotic BH3-only protein NOXA |
[20] |
|
• Included in a SNAIL recruited repressor complex that controls E-cadherin expression, EMT and metastasis |
[54] |
HDAC6 |
• Contributes to aggresome formation and reduces efficiency of proteasome inhibitors |
[49] |
HDAC7 |
• Overexpressed in PDAC |
[21] |