Table 1.

Function and expression of individual HDACs in PDAC

HDAC	Function/expression	References
HDAC1	• Co-expression of HIF-1α and HDAC1 correlates with poor prognosis	[19]
	• Included in a SNAIL recruited repressor complex that controls E-cadherin expression, EMT and metastasis	[54]
HDAC2	• Overexpressed, especially in G2 (moderately-) and G3 (un-) differentiated PDAC	[20]
	• Mediates resistance towards DNA-damage induced apoptosis by controlling expression of the pro-apoptotic BH3-only protein NOXA	[20]
	• Included in a SNAIL recruited repressor complex that controls E-cadherin expression, EMT and metastasis	[54]
HDAC6	• Contributes to aggresome formation and reduces efficiency of proteasome inhibitors	[49]
HDAC7	• Overexpressed in PDAC	[21]