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The so-called ‘first-generation scaffolds’ have been studied over the last 5 years in different clinical applications. FDA approved mPCL scaffolds (Osteopore International, Singapore) have been implanted to regenerate the iliac crest after autograft was taken for spinal fusion surgery. Burr hole plugs are used for cranioplasties and deformable but at the same time strong enough sheets for orbital floor reconstructions. Reprinted with permission from Wiley Interscience.
