Table 1.

Pharmacokinetic Profile of Lorcaserin

Absorption
• Oral bioavailability	Unknown
• Tmax	1.5 2 hours
Metabolism
• Pathway	CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP2E1, CYP3A4, human FMO1
• Half-life	Approximately 11 hours
• Protein binding	70%
• Elimination	Approximately 92.3% urine; 2.2% feces

CYP = cytochrome P450; FMO1 = flavin-containing mono-oxygenase 1; T_max = time to peak concentration. From FDA, drug label;¹² and Usmani KA, et al. Drug Metab Dispos J 2012;40:761–771.²²