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. 2009 Jul 20;14(6b):1657–1667. doi: 10.1111/j.1582-4934.2009.00847.x

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© 2009 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

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Fig 2 — Gene targeting by different types of ssODNs in Msh2-deficient ES cells. (A) Unmodified (black bars), LNA-modified (grey bars) and PTO-modified (white bars) ssODN 4n of various length (nt, nucleotides) and polarity (sense or antisense) were used to correct the mutant neo gene in Msh2-deficient ES cells. (B) Correction of the mutant neo gene by unmodified (black bars), LNA-modified (grey bars) and PTO-modified (white bars) ssODN 1m. (C) Correction of the mutant neo gene by unmodified (black bars), LNA-modified (grey bars) and PTO-modified (white bars) ssODN 4N. Targeting efficiency is the number of G418-resistant colonies per 10⁵ cells that were plated after ssODN exposure. Error bars represent the standard deviation (S.D.) of at least three independent experiments.