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Proposed model for t-PA regulation by retinoids in human amnion. (A) First-step regulation of t-PA by a RAR-α-dependent pathway. Before and up to 12 hrs, retinoids simultaneously stimulate t-PA and RAR-β expression through RAR-α signalling. (B) Second-step regulation of t-PA by a RAR-β-delayed pathway. After 12 hrs, RAR-β is able to induce a higher t-PA expression than in the first step.
