PLC isozyme activities in response to norepinephrine in cardiomyocytes transfected with c-Fos and c-Jun siRNA. PLC β1,β3 and δ1 isozyme activities were determined in c-Fos and c-Jun transfected cardiomyocytes treated with 5 μM NE by measuring hydrolysis of [3H]-PIP2 as described in ‘materials and methods’ section. Values are mean ± S.E. of five experiments performed with five different cardiomyocyte preparations. *Significantly different (P < 0.05) versus control; #significantly different (P < 0.05) versus NE. CONT, control; NC, negative control; NE, norepinephrine; siRNA, small interfering RNA.