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Ack1 regulates TRAIL-induced apoptosis independent of EGFR. Shown are the results from Western blot analysis of MCF10A cells treated with EGFR and the ErbB2 dual-specificity inhibitor lapatinib for 1 h, as indicated, followed by treatment with TRAIL for 2 h. Note that inhibition of ErbB signaling did not restore the reduced cleaved caspase-8 and caspase-3 levels in Ack1 knockdown cells. Ctrl, control; pEGFR, phospho-EGFR.
