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. 2013 Sep 19;288(46):32979–32990. doi: 10.1074/jbc.M113.483123

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Neutrophil enzymes disarm PAR1 to attenuate thrombin-stimulated calcium signaling. A, representative traces showing calcium signaling in KNRK-PAR1-eYFP cells in response to TFLLR-NH₂ (TF), thrombin (Thr), NE, and PR3. // indicates 20 min. B, histogram quantifying thrombin-dependent calcium signaling in KNRK-PAR1-eYFP cells following NE treatment for 20 min. C, histogram quantifying thrombin-dependent calcium signaling in KNRK-PAR1-eYFP cells following PR3 treatment for 20 min. Data are expressed as mean ± S.D. as a percentage of the signal triggered by 20 nm thrombin.