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. 2013 Sep 26;288(46):33124–33135. doi: 10.1074/jbc.M113.480210

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Effect of TK40 at wild-type GluN1/N3 receptors. Representative two-electrode voltage clamp recordings of responses from GluN1/N3 receptors expressed in Xenopus oocytes. A and D, potentiation of glycine-activated current response by 3 μm TK40 at GluN1/N3A (A) and GluN1/N3B (D) (potentiation of 1090 ± 280% (n = 5) and 2510 ± 220% (n = 10) at GluN1/N3A and GluN1/N3B, respectively). B and E, responses from GluN1/N3A (B) and GluN1/N3B (E) receptors to increasing concentrations of glycine in the presence of 3 μm TK40. C and F, glycine concentration-response profile at GluN1/N3A (C) and GluN1/N3B (F) in the presence of 3 μm TK40. Data are mean ± S.E. (error bars) from 4–12 oocytes.