TABLE 2.

Newly validated miR-29 targets and their biology

Gene	Biology
Calcr, Ctr (calcitonin receptor)	Decreases resorption and increases osteoclast survival (44)
Cdc42 (cell division cycle 42)	Promotes osteoclast survival and differentiation; regulates rate of actin ring formation (52)
Srgap2 (SLIT-ROBO Rho GTPase-activating protein)	Induces membrane protrusions; knockdown reduces cell adhesion and increases migration (35, 65)
Gpr85 (G protein-coupled receptor 85)	Transiently induced by LPS in macrophages (48, 49)
Cd93 (complement component 1q receptor 1)	Promotes differentiation of monocytes into macrophages (46)
Nfia (nuclear factor I/A)	Negatively controls c-FMS; overexpression inhibits osteoclast formation; increased in Dicer−/− null osteoclast precursors (13, 17)