TABLE 2.
Comparison of actin binding behavior among different paralogs
For each NM II, the percentage of filaments bound to actin or unbound is shown. Bound filaments were classified as type 1 (bound to a single actin filament via one side of the myosin filament; e.g., Fig. 8, A–D), type 2 (bound to a single actin filament by both sides of the myosin filament; e.g., Fig. 8G), type 3 (bound to multiple actin filaments by one side of the myosin filament; e.g., Fig. 8E), or type 4 (bound to multiple actin filaments by both sides of the myosin filament; e.g., Fig. 8F). Each type is quantified as a percentage of all filaments, and types 2, 3, and 4 are not mutually exclusive.
Paralog | Bound | Unbound | Type 1 | Type 2 | Type 3 | Type 4 |
---|---|---|---|---|---|---|
% | % | % | % | % | % | |
NM IIA | 72 | 28 | 15 | 15 | 40 | 43 |
NM IIB | 89 | 11 | 14 | 24 | 66 | 68 |
NM IIB2 | 64 | 36 | 37 | 6 | 14 | 16 |
NM IIC | 47 | 53 | 30 | 3 | 7 | 11 |