Figure 6. Intrinsic disorder (upper characters) of some human proteins involved in the p53-mediated apoptotic signaling pathways and STRING analysis (lower characters) of their interactomes: group IV.

A. and a. ATR (UniProt ID: Q13535); B. and b. p53 (UniProt ID: P04637); C. and c. CHK2 (UniProt ID: O96017); D. and d. CHK1 (UniProt ID: O14757); E. and e. Caspase-3 (UniProt ID: P42574). Intrinsic disorder propensity was evaluated by PONDR-FIT (red curves and pink shadow) and PONDR ^® VLXT (blue curves). The shadow around PONDR-FIT curves represents distribution of statistical errors. STRING database is the online database resource search tool for the Retrieval of Interacting Genes, which provides both experimental and predicted interaction information ⁹². For each protein, STRING produces the network of predicted associations for a particular group of proteins. The network nodes are proteins. The edges represent the functional associations evaluated based on experiments, search of databases, and text mining. The thickness of edges is proportional to the confidence level ⁹².