Table 2. Abundance of disorder-based binding sites in proteins involved in the p53-mediated apoptotic pathways.
| Protein name | UniProt ID | MoRF | AIBS a | Experiment | Reference |
|---|---|---|---|---|---|
| Fibroblast growth factor 1 | P05230 | - | 28–39 | 24–27 (NLS) b | UniProt |
| TRAIL | P50591 | - | 179–189 | ||
| FasL | P48023 | 4–21, 83–101, 133–150 | 9–19, 77–110 | 81–102 | UniProt |
| Fibroblast growth factor receptor 2 | P21802 | - | 7–12, 117–126, 171–178, 380–396, 488–498, 756–761, 808–812 | 764–778 | [ 153] |
| PERP | Q96FX8 | - | 1–15, 177–190 | - | - |
| DR5 | O14763 | 37–55, 100–118, 165–182 | 6–15, 34–57, 214–247, 272–279, 302–312, 339–352 | - | - |
| FAS | P25445 | 1–15, 177–190 | 230–254 | UniProt | |
| PI3K regulatory subunit | O00459 | 487–504, 565–582 | 29–43, 70–84, 109–118, 122–136, 169–183, 218–231, 241–256, 277–298, 312–320, 325–335, 395–400, 484–488, 574–581 | - | - |
| PTEN | P60484 | 386–403 | 316–320, 336–350, 376–380, 397–403 | 391–403 | UniProt |
| AKT1 | P31749 | 414–431 | 56–60, 73–84, 151–155, 406–414, 441–447, 471–480 | - | - |
| Procaspase-8 | Q14790 | 228–245 | 233–242, 399–404, 421–426, 440–444, 472–479 | - | - |
| Mdm2 | Q00987 | 187–205, 228–245, 270–287, 338–356 | 100–108, 189–208, 235–261, 273–284, 296–306, 322–329, 359–367, 399–409 | 145–150, 179–185, 190–202, 223–232 | [ 154], UniProt |
| ATM | Q13315 | 1–18, 1992–2009 | 1–12, 60–64, 896–907, 2558–2563, 2622–2632, 2950–2957 | 1373–1382 | UniProt |
| ATR | Q13535 | - | 2634–2638 | - | - |
| p53 | P04637 | 17–35, 321–338, 374–398 | 11–57, 106–115, 132–141, 232–239, 251–258, 265–277, 322–355, 363–387 | 13–29, 1–39, 33–60, 241–288, 273–280, 326–356, 359–363, 367–388 | UniProt, [ 155– 159] |
| CHK2 | O96017 | 526–543 | 1–26, 35–41, 58–74, 94–110, 415–419, 535–543 | 63–73 | [ 160] |
| CHK1 | O14757 | 285–302, 333–350 | 240–244, 294–300, 334–342 | - | - |
| Caspase-3 | P42574 | 115–133 | 41–53, 114–119 | - | - |
| Caspase-6 | P55212 | 19–37 | - | - | - |
| Caspase-9 | P55211 | - | 71–77, 281–286 | - | - |
| BID | P55957 | - | 17–27, 86–90, 105–111, 148–157 | 76–109 | [ 161] |
| p53PAI-1 | Q9HCN2 | 8–25 | 8–17 | - | - |
| NOXA | Q13794 | - | 38–54 | 19–43 | UniProt |
| BAX | Q07812 | 21–38 | 18–34 | 13–19, 48–81 | [ 162, 163] |
| BCL-2 | P10415 | - | 13–32, 46–51 | - | - |
| PUMA | Q96PG8 | 12–30, 174–192, 231–248 | 1–11, 15–29, 61–80, 85–99, 102–119, 123–261 | - | - |
| Cytochrome c | P99999 | - | 9–18 | - | - |
a ANCHOR-indicated binding site. Numbers shown in italic correspond to regions (longer than 5 residues) that were predicted as potential binding site by ANCHOR, but filtered due to low IUPred disorder scores (below 0.1) 86, 87.
b NLS, Nuclear localization signal.
MoRF, Molecular recognition feature.