Table 3.
Associations of the presenting symptoms and disease severity
| Total | Chronic | Mild-moderate | Advanced-accelerated | Aggressive-malignant | P* | |
|---|---|---|---|---|---|---|
| Polysymptomatic onset | 169 | 10 (25.6) | 71 (47.0) | 50 (54.9) | 38 (66.7) | < 0.001 |
| Difficulty in walking | 96 | 3 (7.7) | 29 (19.2) | 35 (38.9) | 29 (50.9) | < 0.001 |
| Lower extremity dysfunction | 71 | 3 (7.7) | 16 (10.6) | 31 (34.1) | 21 (36.8) | < 0.001 |
| Upper extremity dysfunction | 45 | 2 (5.1) | 17 (11.3) | 16 (17.6) | 10 (17.5) | 0.030 |
| Reduced visual acuity (optic neuritis) | 114 | 13 (33.3) | 61 (40.4) | 28 (30.8) | 12 (21.1) | 0.031 |
| Sexual dysfunction | 1 | 0 (0) | 0 (0) | 0 (0) | 1 (1.8) | 0.172 |
| Bladder/bowel dysfunction | 21 | 2 (5.1) | 6 (4.0) | 9 (9.9) | 4 (7.0) | 0.190 |
| Fatigue | 31 | 1 (2.6) | 15 (9.9) | 8 (8.8) | 7 (12.3) | 0.261 |
| Sensory symptoms (pain, paresthesia, Lhermitte's sign) | 140 | 18 (46.2) | 62 (41.1) | 40 (44.0) | 20 (35.1) | 0.471 |
| Facial motor symptoms | 11 | 1 (2.6) | 4 (2.6) | 3 (3.3) | 3 (5.3) | 0.398 |
| Facial sensory symptoms | 19 | 3 (7.7) | 8 (5.3) | 5 (5.5) | 3 (5.3) | 0.737 |
| Oculomotor impairment | 68 | 7 (17.9) | 33 (21.9) | 15 (16.5) | 13 (22.8) | 0.975 |
| Vertigo, hypoacousia | 43 | 4 (10.3) | 20 (13.2) | 9 (9.9) | 10 (17.5) | 0.575 |
| Speech/swallowing impairment | 5 | 0 (0) | 3 (2.0) | 1 (1.1) | 1 (1.8) | 0.831 |
| Mental deterioration | 4 | 0 (0) | 1 (.7) | 2 (2.2) | 1 (1.8) | 0.231 |
| Psychiatric symptoms | 5 | 0 (0) | 3 (2.0) | 1 (1.1) | 1 (1.8) | 0.831 |
| Paroxysmal symptoms | 6 | 1 (2.6) | 1 (.7) | 2 (2.2) | 2 (3.5) | 0.347 |
*
Based on Mann-Whitney test