Table 6.
Comparison of univariate and multivariate analysis
| Parameter | Univariate* | Multivariate** | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| OR | 95% CI | P | OR | 95% CI | P | |
| Gender | 0.260 | |||||
| Female | 1(Ref) | - | 1(Ref) | - | ||
| Male | 1.32 | 0.81-2.16 | 1.00 | 0.49-2.04 | 0.994 | |
| Age at disease onset (years) | 1.03 | 1.01-1.06 | 0.004 | 0.96 | 0.93-1.00 | 0.042 |
| Disease duration | 1.03 | 0.99-1.07 | 0.088 | 0.93 | 0.88-0.99 | 0.017 |
| Education (years) | < 0.001 | 0.074 | ||||
| > 16 | 1 (Ref) | - | 1 (Ref) | - | ||
| 12-16 | 0.89 | 0.34-2.34 | 0.46 | 0.15-1.40 | ||
| 5-12 | 1.88 | 0.73-4.82 | 0.71 | 0.23-2.16 | ||
| < 5 | 6.02 | 1.81-20.1 | 2.21 | 0.47-10.34 | ||
| Positive family history | 0.805 | |||||
| No | 1 (Ref) | - | ||||
| Yes | 1.08 | 0.59-1.96 | 0.87 | 0.42-1.80 | 0.700 | |
| Disease course | < 0.001 | < 0.001 | ||||
| RR | 1 (Ref) | - | ||||
| SP | 28.81 | 15.08-55.02 | 49.14 | 16.14-149.62 | ||
| PP + PR | 44.49 | 20.56-94.51 | 53.25 | 21.26-133.37 | ||
| Number of symptoms | 1.31 | 1.14-1.49 | < 0.001 | 1.03 | 0.73-1.46 | 0.852 |
| Polysymptomatic onset | ||||||
| No | 1 (Ref) | - | ||||
| Yes | 2.24 | 1.49-3.33 | < 0.001 | - | - | |
| Presenting symptoms | ||||||
| Difficulty in walking | 3.72 | 2.37-5.83 | < 0.001 | 2.31 | 0.98-5.42 | 0.055 |
| Lower extremity dysfunction | 3.74 | 2.30-6.10 | < 0.001 | 1.91 | 0.73-4.99 | 0.189 |
| Upper extremity dysfunction | 1.85 | 1.05-3.24 | 0.033 | 0.66 | 0.26-1.68 | 0.388 |
| Optic neuritis | 0.64 | 0.42-0.96 | 0.033 | 0.61 | 0.27-1.36 | 0.225 |
| Bladder/bowel dysfunction | 1.68 | 0.76-3.7 | 0.196 | 1.62 | 0.51-5.16 | 0.417 |
| Sensory symptoms | 0.86 | 0.58-1.29 | 0.471 | 0.73 | 0.35-1.52 | 0.397 |
| Oculomotor impairment | 0.99 | 0.61-1.62 | 0.975 | 0.80 | 0.34-1.87 | 0.605 |
| Vertigo, hypoacousia | 1.19 | 0.65-2.16 | 0.569 | 0.97 | 0.37-2.57 | 0.951 |
OR: Odds ratio for getting worse conditions
*
Based on ordinal logistic regression
**
Based on multiple ordinal logistic regression