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Binding affinity of wild-type and variants of hnRNP L RRM34 with 5′(CA)213′ RNA by SPR assays
| KDa | KD relative to WT | |
|---|---|---|
| nm | ||
| Wild type RRM34 | 22 ± 1 | 1 |
| Y387A | 48 ± 1 | 2 |
| K413A | 60 ± 6 | 3 |
| S454A | 30 ± 1 | 1 |
| I459A | 43 ± 3 | 2 |
| P461A | 18 ± 3 | 1 |
| R495A | 43 ± 1 | 2 |
| H504A | 3.1 ± 0.1 × 102 | 14 |
| F506A | 3.8 ± 0.1 × 102 | 17 |
| K533A | 15 ± 1 | 1 |
| F535A | 40 ± 2 | 2 |
| K579A | 83 ± 4 | 4 |
a Values are based on two or three independent experiments, and the mean ± S.E. is indicated.
