. Author manuscript; available in PMC: 2013 Nov 15.

Published in final edited form as: Gastroenterology. 2010 Feb 19;138(4):10.1053/j.gastro.2010.02.037. doi: 10.1053/j.gastro.2010.02.037

Table 1.

Family Studies of IBS

Citation	Finding
Whorwell et al, Gut 1986⁴⁹	33% of patients with IBS vs 2% of controls have a family history of IBS
Bellentani et al, Fam Pract 1990⁵⁰	IBS in a first-degree relative predicts a diagnosis of IBS in patients with abdominal pain
Locke et al, Mayo Clin Proc 2000⁵¹	Reporting a relative with abdominal pain or altered bowel habit predicts IBS (odds ratio, 2.5; 95% confidence interval, 1.5–4.2)
Levy et al, Am J Gastroenterol 2000⁵²	Health maintenance organization database study: children of parents with IBS are more likely to present to providers with abdominal pain than children of parents without IBS
Kanazawa et al, Dig Dis Sci 2004⁵³	Familial aggregation of IBS is not due to the result of psychological factors or psychiatric disorders
Saito et al, Neurogastroenterol Motil 2008⁸	Case relatives are 3 times more likely to meet Rome criteria for IBS than control relatives by direct survey