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. 2013 Oct 10;2:134. Originally published 2013 May 31. [Version 2] doi: 10.12688/f1000research.2-134.v2

Figure 5.

Figure 5.

( a) FAM129B expression associates with an invasive cohort of patient melanomas. FAM129B gene expression was compared between three previously identified melanoma cohorts. We compared FAM129B expression in cohorts A and B with cohort C. Log(2) transformed expression for FAM129B was significantly higher in cohort C than in cohorts A and B (8.962 ± 0.1355 vs 9.629 ± 0.2795, p= 0.0214) ( b) FLAG-purification of FLAG-GFP-FAM129B unveils multiple FAM129B interactors. Nodes depict FAM129B interacting proteins identified by affinity purification/mass spectrometry. Bait protein Flag-GFP-FAM129B is depicted in yellow. Prey proteins are depicted in blue. ( c) Model of FAM129B regulation by ERK/MAPK signaling in melanoma and regulation of Wnt/β-catenin signaling. FAM129B is a substrate downstream of active MEK (green) that is required for melanoma invasion 13. We identified FAM129B as a positive regulator of Wnt/β-catenin signaling (blue).