TABLE 3.
Structure-function analysis of hGLUT2
Loop, loop between transmembrane domains; WT, wild-type hGLUT2; NA, nonapplicable; ND, not determined.
| Mutation | Found in human | Amino acid location | Domain function | Plasma membrane expression | Transport activity | Receptor activity |
|---|---|---|---|---|---|---|
| G20D | FBS | TM1 | Unknown | No | NA | ND |
| G20S | TM1 | Unknown | Yes | High | High with or without glucose | |
| P68L | SNP | Loop 1 | Unknown | Yes | As WT | ND |
| T110I | SNP | TM2 | Unknown | Yes | As WT | ND |
| S242R | FBS | Loop 6 | PESPR signature | No | None | ND |
| F295Y | Loop 6 | Signaling | Yes | Close to WT | High without glucose | |
| L368P | TM9 | Sugar tunnel | Yes | Low | High without glucose | |
| P417L | FBS | TM10 | Sugar tunnel | Yes | None | ND |
| W444R | FBS | TM11 | Sugar-binding site | Yes | None | ND |