Fig. 1.

Dose-dependent exacerbation of Con A-induced liver injury by TCDD. Mice were treated on day 0 with 0, 0.3, 3, or 30 μg/kg of TCDD. After 4 days, they were given 6mg/kg Con A or saline. ALT activity in plasma was measured 8h after Con A or saline administration. a, p < 0.05 vehicle/Con A versus vehicle/saline. b, p < 0.05 TCDD/Con A versus the same TCDD dose with saline treatment. c, p < 0.05 TCDD/Con A versus vehicle/Con A. Data represent the mean ± SE of 3–6 independent replicates per treatment group.