Fig. 9.

The effect of NK cell depletion on TCDD/Con A-mediated liver injury (A) and IFNγ production (B). Mice were treated as described in the legend to Figure 2 with vehicle (white bars) or TCDD (gray bars) on day 0, then treated with either normal rabbit serum (open bars) or rabbit anti-mouse/rat asialoGM1 polyclonal antibody (striped bars), as described in Materials and Methods section, 18h prior to the administration of 6mg/kg (white and gray bars) or 20mg/kg (black bars) Con A. c, p < 0.05 versus vehicle/6mg/kg Con A in the same control serum or anti-asialo treatment. f, p < 0.05 versus the same treatment with control serum. Data represent the mean ± SEM of 7–11 independent replicates for all groups treated with 6mg/kg Con A and 3–4 independent replicates for all groups treated with 20mg/kg Con A. Data were combined from 2 separate experiments.