TABLE 3.
Associations of SLCO1B1 Genotypes With % Arsenic Species From Measured Genotype Analysis
| SNP | Trait | p Value | h 2 m | μAA | SE(μAA) | μAB | SE(μAB) | μBB | SE(μBB) | p for Population Stratification |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1564370 | %iAs | .010 | 0.04 | 12.8 | 0.9 | 11.5 | 0.8 | 10.2 | 1.0 | 1.00 |
| %MMA | < .001 | 0.08 | 17.3 | 0.9 | 15.4 | 0.7 | 13.5 | 0.9 | .44 | |
| %DMA | < .001 | 0.09 | 70.0 | 1.4 | 73.3 | 1.2 | 76.6 | 1.6 | .89 | |
| rs2291075 | %iAs | .124 | 0.01 | 11.8 | 0.8 | 10.3 | 1.1 | 8.9 | 1.9 | .61 |
| %MMA | < .001 | 0.07 | 16.0 | 0.7 | 12.8 | 1.1 | 9.6 | 1.9 | .03 | |
| %DMA | .001 | 0.05 | 72.2 | 1.3 | 77.3 | 1.9 | 82.4 | 3.2 | .24 | |
| rs2417955 | %iAs | .607 | < 0.01 | 11.8 | 0.8 | 11.5 | 0.9 | 11.1 | 1.3 | 1.00 |
| %MMA | .185 | 0.01 | 16.0 | 0.8 | 15.0 | 0.8 | 14.1 | 1.3 | .05 | |
| %DMA | .225 | < 0.01 | 72.3 | 1.4 | 73.7 | 1.5 | 75.1 | 2.3 | .09 | |
| rs2900478 | %iAs | .092 | 0.02 | 11.9 | 0.8 | 9.5 | 1.5 | 7.2 | 2.7 | .48 |
| %MMA | .120 | 0.02 | 15.8 | 0.7 | 13.6 | 1.5 | 11.4 | 2.8 | .77 | |
| %DMA | .075 | 0.02 | 72.4 | 1.3 | 76.7 | 2.5 | 81.0 | 4.7 | .84 | |
| rs4149063 | %iAs | .492 | < 0.01 | 11.4 | 0.9 | 11.9 | 0.8 | 12.3 | 1.2 | 1.00 |
| %MMA | .317 | < 0.01 | 15.1 | 0.9 | 15.9 | 0.8 | 16.6 | 1.3 | .76 | |
| %DMA | .372 | < 0.01 | 73.5 | 1.5 | 72.4 | 1.4 | 71.3 | 2.1 | .58 |
Note. The h 2 m is the proportion of the residual phenotypic variance explained by the minor allele. Means and standard errors for each % arsenic species biomarker are presented according to genotype, adjusting for study center, sex, and body mass index, along with a p value for significance of the association and p value for evidence for population stratification. “A” corresponds to the major allele and “B” corresponds to the minor allele for each SNP. Abbreviations: µ, Mean.