Table 3.
SF+ tumors with increased expression of genes implicating ECM signaling
| Term | Count | Genes |
|---|---|---|
| SF+ downregulated pathways | ||
| hsa04080: Neuroactive ligand-receptor interaction | 22 | GABRD, GABRG2, PARD3, GABRA1, GABRB3, GRIK2, GRIN1, PTH1R, GRIK4, HTR4, GRIA4, VIPR2, GRM4, GRM3, SSTR2, HRH3, GRIN2C, SSTR1, CHRM1, PRSS3, ADRA1A, GRID1 |
| hsa04020: Calcium signaling pathway | 13 | SLC8A3, SLC8A2, ERBB3, GRIN1, HTR4, PRKCB, GNAL, ATP2B3, GRIN2C, CHRM1, RYR1, ADRA1A, CACNA1A |
| hsa05200: Pathways in cancer | 15 | FGF8, BMP2, RET, HSP90AA1, BCR, FGF12, ZBTB16, CTNNA3, PRKCB, WNT7B, CDKN2B, NTRK1, BCL2, PTCH1, PIK3R1 |
| hsa05412: Arrhythmogenic right ventricular cardiomyopathy | 6 | CACNG6, SGCD, CACNG3, CACNG2, SGCA, CTNNA3 |
| hsa04144: Endocytosis | 10 | SH3GL3, RET, RAB11FIP2, PARD3, CLTA, CLTB, ERBB3, NTRK1, AGAP2, EPN2 |
| hsa05410: Hypertrophic cardiomyopathy | 6 | MYL3, CACNG6, SGCD, CACNG3, CACNG2, SGCA |
| hsa05414: Dilated cardiomyopathy | 6 | MYL3, CACNG6, SGCD, CACNG3, CACNG2, SGCA |
| SF+ upregulated pathways | ||
| hsa04060: Cytokine-cytokine receptor interaction | 18 | CSF3, CCL2, TNFRSF12A, IL7, IL21R, MET, CXCL2, CCL8, CD70, IL15, CCL27, TNFRSF11A, IL12RB1, CXCL14, CCL20, IL1RAP, VEGFA, IL1B |
| hsa04512: ECM-receptor interaction | 7 | IBSP, COL6A3, ITGA11, LAMC1, COL5A1, HMMR, FN1 |
| hsa04621: NOD-like receptor signaling pathway | 6 | CCL2, CXCL2, CCL8, IL1B, TNFAIP3, BIRC3 |
| hsa00360: Phenylalanine metabolism | 4 | ALDH1A3, ALDH3B1, ALDH3A1, HPD |
| hsa00350: Tyrosine metabolism | 5 | ALDH1A3, METTL2B, ALDH3B1, ALDH3A1, HPD |
| hsa00340: Histidine metabolism | 4 | ALDH1A3, METTL2B, ALDH3B1, ALDH3A1 |
| hsa04510: Focal adhesion | 10 | IBSP, RAC2, MET, VEGFA, COL6A3, ITGA11, LAMC1, BIRC3, COL5A1, FN1 |
| hsa04630: JAK-STAT signaling pathway | 8 | CSF3, SPRY1, IL12RB1, IL7, SOCS1, IL21R, IL15, IL13RA2 |
| hsa04114: Oocyte meiosis | 6 | INS, PLK1, SGOL1, CAMK2D, CDC20, AURKA |
| hsa04950: Maturity onset diabetes of the young | 3 | BHLHA15, INS, HNF4G |
| hsa04612: Antigen processing and presentation | 5 | CIITA, PDIA3, HSPA7, KIR2DL1, HLA-C |
Abbreviations: NOD, nucleotide-binding oligomerization domain; JAK-STAT, Janus kinase/signal transducers and activators of transcription. Overview of pathways differentially expressed between SF+ and SF−/SFnp tumors. KEGG pathway analysis on ANOVA-derived gene lists comparing SF+ with SF−/SFnp tumors were uploaded and mapped according to the KEGG annotation tool in DAVID. Significant pathways and associated genes are depicted by official gene symbol.