Table 4.
Treatment HRs and 95% CIs for death
| HR (95% CI) (each column represents a separate multivariate Cox modela) | |||||||
|---|---|---|---|---|---|---|---|
| Model 1: Surgeryb | Model 2: Radiotherapyc | Model 3: First Course Non-TMZ Chemotherapyd | Model 4: First Course TMZ Chemotherapye | ||||
| Full cohort: 1618 deaths/1645 cases | |||||||
| Biopsy only (424/426)f | 1.00 (reference) | No (402/404) | 1.00 (reference) | No (1451/1476) | 1.00 (reference) | No (1058/1063) | 1.00 (reference) |
| Partial resection (641/654) | 0.53 (0.46–0.60) | Yes (1179/1203) | 0.51 (0.45–0.59) | Yes (143/145) | 0.83 (0.69–0.99) | Yes (540/562) | 0.52 (0.45–0.60) |
| Gross total resection (263/271) | 0.41 (0.35–0.48) | P | <.0001 | P | .036 | P | <.0001 |
| Resection NOS (290/294) | 0.45 (0.39–0.53) | ||||||
| P | <.0001 | ||||||
| Restricted cohort (treated with resection and radiotherapy): 910 deaths/932 cases | |||||||
| No (778/798) | 1.00 (reference) | No (489/491) | 1.00 (reference) | ||||
| Yes (116/118) | 0.87 (0.71–1.06) | Yes (406/426) | 0.60 (0.49–0.73) | ||||
| P | .17 | P | <.0001 | ||||
Abbreviation: NOS, not otherwise specified.
aAdjusted for period of diagnosis (1997–2000, 2001–2004, 2005–2008), age at diagnosis (≤39 y, 40–44, 45–49, … 80–84, 85+), and baseline Charlson comorbidity score (0, ≥1, unknown), with no adjustment for other treatments.
bSurgery (biopsy only, partial resection, gross total resection, resection NOS), modeled as a time-updated variable.
cRadiotherapy (no, yes, unknown), modeled as a time-updated variable.
dFirst course non-TMZ chemotherapy (no, yes, unknown), modeled as a time-updated variable.
eFirst course TMZ chemotherapy (no, yes, unknown), modeled as a time-updated variable.
fDeaths/cases; in each model, numbers in categories may not add to the total number in the cohort because results for the unknown category are not shown.