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. 2013 Sep 17;15(12):1750–1761. doi: 10.1093/neuonc/not122

Table 5.

Period of diagnosis HRs and 95% CIs for death

Univariate HR (95% CI) Multivariate HR (95% CI)
Deaths/Cases Basea Base + Surgeryb Base + Surgery + Radiotherapyc Base + Surgery + Radiotherapy + First Course Non-TMZ Chemod Base + Surgery + Radiotherapy + First Course Non-TMZ Chemo + First Course TMZ Chemoe
Full cohort: 1618 deaths/1645 cases
 Period of diagnosis
 1997–2000 516/518 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference)
 2001–2004 582/586 0.96 (0.85–1.08) 0.91 (0.80–1.02) 0.91 (0.81–1.03) 0.92 (0.81–1.04) 0.91 (0.80–1.03) 1.06 (0.93–1.21)
 2005–2008 520/541 0.82 (0.73–0.93) 0.72 (0.64–0.82) 0.70 (0.62–0.80) 0.74 (0.65–0.84) 0.73 (0.64–0.83) 1.01 (0.86–1.19)
 Period effect P .0040 <.0001 <.0001 <.0001 <.0001 .60
 Trend P .0015 <.0001 <.0001 <.0001 <.0001 .84
Restricted cohort (treated with resection and radiotherapy): 910 deaths/932 cases
 Period of diagnosis
 1997–2000 303/305 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference)
 2001–2004 324/327 0.87 (0.75–1.02) 0.81 (0.69–0.95) 0.81 (0.69–0.95) 0.81 (0.69–0.96) 0.80 (0.68–0.94) 1.05 (0.87–1.25)
 2005–2008 283/300 0.71 (0.60–0.83) 0.60 (0.51–0.71) 0.61 (0.52–0.73) 0.62 (0.52–0.73) 0.60 (0.51–0.72) 1.02 (0.79–1.31)
 Period effect P .0002 <.0001 <.0001 <.0001 <.0001 .86
 Trend P <.0001 <.0001 <.0001 <.0001 <.0001 .86

Abbreviations: Chemo, chemotherapy; CI, confidence interval; HR, hazard rate ratio; TMZ, temozolomide.

aAdjusted for age at diagnosis (≤39 y, 40–44, 45–49, … 80–84, 85+) and baseline Charlson comorbidity score (0, ≥1, unknown).

bAdditionally adjusted for surgery (biopsy only, partial resection, gross total resection, resection not otherwise specified), modeled as a time-updated covariate.

cAdditionally adjusted for radiotherapy (no, yes, unknown), modeled as a time-updated covariate.

dAdditionally adjusted for first course non-TMZ chemotherapy (no, yes, unknown), modeled as a time-updated covariate.

eAdditionally adjusted for first course TMZ chemotherapy (no, yes, unknown), modeled as a time-updated covariate.