Table 2.

General features of the 12 selected protocols

Protocol	Slice	Direction of tracing	MR Sequence	Validation Sample	Included Hippocampal tissue	Reproducibility measures
Bartzokis et al., 1998 [21]	coronal	from rostral to caudal	T1	healthy controls	Head, body, and tail until visualization of colliculi	5% error
Convit et al., 1997 [26]	coronal	from rostral to caudal	T1	AD	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	0.85 inter-rater reliability (ICC)
deToledo-Morrell et al., 2004 [23]	coronal	from rostral to caudal	T1	MCI	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	0.97 intra-rater and inter-rater reliability (ICC)
Haller et al., 1997 [27]	coronal, sagittal and axial	from caudal to rostral	T1	schizophrenia	Head, body, and whole tail	77.9% overlap of voxels
Jack et al., 1994 [17]	coronal	from caudal to rostral	T1	epilepsy	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	1.2% and 3.4% intra- and inter-observer variability (5% error with slices below a thickness of 3mm)
Killiany et al., 1993 [24]	coronal	from rostral to caudal	T1	AD	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	0.91 and 0.92 intra- and inter-rater reliability (ICC)
Lehericy et al., 1994 [25]	coronal	from caudal to rostral	T1	AD	Head, body, and tail ntil visualization of crus/crura of fornix/ces in full profile	7% inter-rater relative error on volume [81]
Malykhin et al., 2007 [20]	coronal; sagittal at the level of the head	from the hippocampal body to the tail, then from the posterior part of head to its rostral part	T1	Parkinson’s disease; depression	Head, body, and whole tail	0.86 and 0.96 intra- and inter-rater reliability (ICC)
Pantel et al., 2000 [19]	coronal	from rostral to caudal	T1+ T2	healthy controls	Head, body, and whole tail	intraclass R = 0.78
Pruessner et al., 2000 [18]	coronal	from caudal to rostral	T1	healthy controls	Head, body, and whole tail	0.92 and 0.99 intra- and inter-rater reliability (ICC)
Soininen et al., 1994 [28]	coronal	from rostral to caudal	T1	MCI	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	0.95 intra-rater reliability (ICC)
Watson et al., 1992 [29]	coronal	from rostral to caudal	T1	healthy controls	Head, body, and tail until visualization of crus/crura of fornix/ces in full profile	intra-rater score range between 0.88 and 0.99